David Watkins Selected Research

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)

1/2022	Inherited defects of cobalamin metabolism.
7/2012	Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
7/2002	Hyperhomocysteinemia due to methionine synthase deficiency, cblG: structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L.

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David Watkins Research Topics

Disease

22	Neoplasms (Cancer) 01/2022 - 04/2009
16	Methylmalonic acidemia 10/2022 - 12/2004
12	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 10/2007
7	Adenocarcinoma 01/2022 - 12/2014
7	Megaloblastic Anemia 01/2020 - 01/2003
6	Homocystinuria 10/2022 - 07/2002
5	Infections 01/2020 - 10/2007
5	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2020 - 09/2011
5	Methylenetetrahydrofolate reductase deficiency 08/2014 - 01/2003
3	Carcinoma (Carcinomatosis) 01/2022 - 01/2017
3	Pancreatic Neoplasms (Pancreatic Cancer) 11/2021 - 11/2009
3	Rectal Neoplasms (Rectal Cancer) 01/2020 - 04/2009
2	Arakawa syndrome 2 01/2022 - 07/2012
2	Intrinsic Factor Deficiency 01/2022 - 02/2011
2	COVID-19 01/2021 - 01/2020
2	Melanoma (Melanoma, Malignant) 01/2021 - 04/2009
2	Hereditary Folate Malabsorption 01/2020 - 07/2012
2	Hyperhomocysteinemia 09/2013 - 07/2002
2	Atypical Hemolytic Uremic Syndrome 02/2013 - 07/2012
2	Glutamate formiminotransferase deficiency 07/2012 - 07/2003
2	Methylmalonic acidemia with homocystinuria 07/2009 - 01/2006
2	Non-Hodgkin Lymphoma (Lymphosarcoma) 02/2007 - 09/2002
1	alpha-Thalassemia 07/2022
1	Metabolic Diseases (Metabolic Disease) 07/2022
1	Hemorrhage 01/2022
1	Exocrine Pancreatic Insufficiency 03/2021
1	Urinary Tract Infections (Urinary Tract Infection) 03/2021
1	Vitamin B 12 Deficiency (Vitamin B12 Deficiency) 03/2021
1	Glioma (Gliomas) 01/2021
1	Pain (Aches) 01/2020
1	Reinfection 01/2020
1	Hematoma 01/2020
1	Hematuria 01/2020
1	Thrombosis (Thrombus) 01/2020
1	Sepsis (Septicemia) 01/2020
1	Vasovagal Syncope 01/2020
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2020
1	Rheumatic Fever (Acute Articular Rheumatism) 11/2019
1	Neoplasm Metastasis (Metastasis) 05/2019
1	Chromosomal Instability (Chromosome Stability) 05/2019

Drug/Important Bio-Agent (IBA)

18	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 10/2022 - 09/2005
8	Folic Acid (Vitamin M)FDA LinkGeneric 01/2020 - 01/2003
7	HomocysteineIBA 01/2022 - 01/2003
6	EnzymesIBA 07/2016 - 07/2003
5	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 01/2015
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 03/2016
4	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2020
4	cobamamide (adenosylcobalamin)IBA 01/2022 - 12/2004
4	Coenzymes (Enzyme Cofactors)IBA 01/2022 - 09/2013
4	Cetuximab (Erbitux)FDA Link 01/2021 - 03/2016
4	VitaminsIBA 01/2020 - 01/2003
4	Transcobalamins (Transcobalamin II)IBA 01/2020 - 09/2009
4	Methylmalonic AcidIBA 12/2016 - 09/2009
3	mecobalamin (methylcobalamin)IBA 01/2022 - 07/2002
3	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)IBA 01/2022 - 07/2002
3	Fluorouracil (Carac)FDA LinkGeneric 01/2022 - 04/2009
3	Leucovorin (Folinic Acid)FDA Link 01/2022 - 04/2009
3	Methylmalonyl-CoA MutaseIBA 01/2022 - 10/2007
3	AntibodiesIBA 01/2021 - 09/2009
3	Methionine (L-Methionine)FDA Link 01/2021 - 04/2009
3	Calcibiotic Root Canal SealerIBA 01/2021 - 01/2019
3	ErbB Receptors (EGF Receptor)IBA 01/2021 - 10/2007
3	Gemcitabine FDA Link 11/2009 - 09/2002
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2022 - 11/2021
2	ibrutinibIBA 01/2022 - 11/2019
2	folfirinoxIBA 11/2021 - 12/2014
2	Circulating Tumor DNAIBA 01/2020 - 01/2016
2	Methylenetetrahydrofolate Dehydrogenase (NADP) (Dehydrogenase, Methylenetetrahydrofolate)IBA 01/2020 - 07/2012
2	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 08/2014
2	Biological ProductsIBA 11/2019 - 11/2009
2	PlatinumIBA 11/2018 - 01/2017
2	Cell-Free Nucleic AcidsIBA 11/2018 - 10/2018
2	Cisplatin (Platino)FDA LinkGeneric 10/2018 - 02/2007
2	Penicillin G Benzathine (Benzathine Benzylpenicillin)FDA Link 02/2017 - 05/2016
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2017 - 03/2016
2	Betaine (C.B.B.)FDA Link 08/2014 - 07/2014
2	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 07/2014 - 01/2003
2	Proteins (Proteins, Gene)FDA Link 07/2012 - 04/2009
2	methylmalonyl-coenzyme A racemase (methylmalonyl-CoA epimerase)IBA 10/2007 - 08/2006
2	Nonsense Codon (Nonsense Mutation)IBA 08/2006 - 05/2003
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 07/2022
1	Docetaxel (Taxotere)FDA Link 01/2022
1	Irinotecan (Camptosar)FDA LinkGeneric 11/2021
1	MicroRNAs (MicroRNA)IBA 11/2021
1	Bile Acids and Salts (Bile Acids)IBA 03/2021
1	CateninsIBA 01/2021
1	ChromatinIBA 01/2021
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2021
1	Panitumumab (Vectibix)FDA Link 01/2021
1	Monoamine Oxidase (MAO)IBA 01/2021
1	Cell ExtractsIBA 01/2020
1	Indicators and Reagents (Reagents)IBA 01/2020
1	InterferonsIBA 11/2019
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2019
1	GTP-Binding Proteins (G-Protein)IBA 01/2019

Therapy/Procedure

14	Therapeutics 01/2020 - 02/2007
12	Drug Therapy (Chemotherapy) 01/2022 - 09/2002
2	Chemoradiotherapy 10/2018 - 01/2017
1	Conservative Treatment 01/2020
1	Length of Stay 11/2019